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Cover Page

RECURRENT PREGNANCY LOSS CARE

Expert Care for Recurrent Pregnancy Loss and Recurrent Miscarriage

You're not alone. Comprehensive evaluation, compassionate support, and advanced treatments to help you achieve a healthy pregnancy after recurrent miscarriage.

Book Your Consultation Understand Your Options 
Comprehensive evaluation • Evidence-based treatment • Compassionate support
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📅
Complete RPL Workup
Evidence-based testing to identify treatable causes.
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Genetic Testing & Counselling
Parental and embryo screening with expert guidance.
❤️
Personalised Treatment Plans
Care directed at your specific diagnosis and goals.
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Emotional Support Throughout
Counselling and community alongside medical care.

Understanding Recurrent Pregnancy Loss

Recurrent Pregnancy Loss (RPL), also known as recurrent miscarriage, is defined as two or more consecutive clinical pregnancy losses before 20 weeks of gestation. This condition affects 1–2% of couples trying to conceive and can be emotionally devastating.

Modern definition: 2 or more losses (previously 3 or more). Evaluation is now recommended after 2 losses.

15–25%
Of recognized pregnancies end in miscarriage
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✔

Affects 1–2% of couples

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50–60% due to chromosomal abnormalities

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Many causes are treatable

“

We understand the profound grief and heartbreak that comes with each loss. You are not alone, and there is hope. Our team is here to support you through every step of this journey.

— The StemRx IVF Team

Common Causes of Recurrent Pregnancy Loss

RPL can result from multiple factors. In approximately 50% of cases, a specific cause can be identified and treated.

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Most Common

Genetic Factors
Random chromosomal abnormalities in the embryo account for 50–60% of early miscarriages. Parental balanced translocations occur in 2–5% of couples with RPL.
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Treatable

Antiphospholipid Syndrome (APS)
An autoimmune disorder causing blood clots in placental vessels. Present in 5–20% of women with RPL. Highly treatable with anticoagulation therapy.
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Uterine Structural Abnormalities
Congenital anomalies (septate uterus, bicornuate uterus) and acquired conditions (fibroids, polyps, adhesions) account for 10–15% of RPL. Many are surgically correctable.
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Hormonal & Metabolic Disorders
Uncontrolled diabetes, thyroid dysfunction, PCOS, and luteal phase defects can contribute to pregnancy loss. Proper management improves outcomes.
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Inherited Thrombophilias
Blood clotting disorders (Factor V Leiden, Prothrombin gene mutation, Protein C/S deficiency) may cause placental thrombosis. Testing and treatment are individualized.
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Additional Contributing Factors
Advanced maternal age, lifestyle factors, environmental exposures, cervical insufficiency, and immune factors may play a role in some cases.

In approximately 50% of cases, no specific cause is identified (unexplained RPL). Even in unexplained cases, many women go on to have successful pregnancies with supportive care.

Comprehensive RPL Evaluation and Testing

A thorough, evidence-based workup to identify treatable causes.

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Complete History
Three-generation family history, reproductive history, timing of losses, gestational age at loss, lifestyle factors, medications, and exposures.
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Genetic Evaluation
Parental karyotyping (both partners), chromosomal analysis of pregnancy tissue if available. Identifies balanced translocations and other chromosomal abnormalities.

2–5% of RPL couples have parental chromosomal rearrangements

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Uterine Evaluation
3D ultrasound, saline sonohysterography (SHG), hysterosalpingography (HSG), or hysteroscopy to detect septum, fibroids, polyps, or adhesions.
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APS Screening
Lupus anticoagulant, anticardiolipin antibodies (IgG/IgM), anti-beta2-glycoprotein-I antibodies. Requires two positive tests 12 weeks apart for diagnosis.

Most important treatable cause

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Hormonal Assessment
TSH and thyroid antibodies, HbA1c for diabetes screening, prolactin, ovarian reserve testing (AMH, Day 3 FSH), assessment for PCOS.
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Targeted Testing
Inherited thrombophilia panel (controversial, case-by-case), immune function tests, endometrial biopsy, sperm DNA fragmentation testing for male partner.

Treatment Based on Identified Cause

Cause-directed therapy significantly improves live birth rates.

🧬 Genetic Abnormalities ▼

Genetic counselling, PGT-A (preimplantation genetic testing for aneuploidy) with IVF, or donor gamete options where a parental chromosomal abnormality is identified.

💧 Antiphospholipid Syndrome (APS) ▼

Low-dose aspirin combined with heparin (anticoagulation therapy) started early in pregnancy significantly improves live birth rates in confirmed APS cases.

🩺 Uterine Structural Abnormalities ▼

Hysteroscopic correction of septum, polyps, fibroids, or adhesions to restore normal uterine cavity shape before attempting pregnancy again.

🧪 Hormonal & Metabolic Conditions ▼

Optimizing thyroid function, blood sugar control, and treating PCOS or luteal phase defects before conception to reduce miscarriage risk.

📈 Inherited Thrombophilias ▼

Individualized anticoagulation therapy based on the specific clotting disorder identified, guided by a hematologist alongside your fertility specialist.

❤️ Unexplained Recurrent Pregnancy Loss ▼

Supportive care, early pregnancy monitoring, and emotional support. Many couples with unexplained RPL go on to have successful pregnancies without specific intervention.

Preimplantation Genetic Testing (PGT-A) for RPL

How PGT-A Helps

PGT-A screens embryos for chromosomal abnormalities before transfer, allowing selection of euploid (chromosomally normal) embryos. This is particularly beneficial for RPL caused by aneuploidy.

✔Reduces miscarriage rates by 50–60% per transfer
✔Increases live birth rate per transfer
✔Reduces time to pregnancy
✔Particularly beneficial for women over 35 years
✔Recommended for couples with chromosomal translocations

Women ≤35 years: PGT-A increased cumulative live birth rate from 51% to 70%.

50–60%
Reduction in miscarriage rate per embryo transfer
60–70%
Live birth rate with PGT-A in women under 35
35%
Live birth rate with PGT-A in women over 35 (vs 21% without)

PGT-A is not appropriate for all RPL cases. Your fertility specialist will discuss whether genetic testing aligns with your specific situation and diagnosis.

Success Rates and Pregnancy Outcomes

With comprehensive evaluation and appropriate treatment, many women with RPL achieve successful pregnancies.

60–70%
Live birth rate in unexplained RPL with supportive care
70–80%
Live birth rate in APS with anticoagulation treatment
50–60%
Reduction in miscarriage rate with PGT-A per transfer
85–90%
Live birth rate after surgical correction of uterine septum

Success rates vary based on individual factors including age, cause of RPL, ovarian reserve, and overall health. These are general estimates from published studies.

Emotional Support Throughout Your Journey

Recurrent pregnancy loss takes an emotional toll. We provide comprehensive psychological support alongside medical treatment.

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Individual Counselling
One-on-one sessions with fertility counsellors specializing in pregnancy loss and grief.
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Support Groups
Connect with other women and couples who understand your experience.
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Stress Reduction
Mindfulness, yoga, meditation, and relaxation techniques to support mental wellbeing.

Why Choose StemRx for Recurrent Pregnancy Loss Care

Turning Hope Into Reality

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Comprehensive RPL Workup
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Advanced Genetic Testing (PGT-A, PGT-SR)
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Multidisciplinary Team Approach
❤️
Personalised, Evidence-Based Treatment
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Compassionate Emotional Support

Your Care Journey at StemRx

1
Initial consultation and history review
2
Comprehensive diagnostic evaluation
3
Identification of underlying causes
4
Personalised treatment planning
5
Treatment implementation
6
Early pregnancy monitoring and support
7
Continued care throughout pregnancy
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Dr. Mahajan Hospital & ITC, Near Shell Petrol Pump,

R-831, Thane Belapur Road, Rabale, 

Navi Mumbai - 400708

To Book an Appointment : 91+9152215415

Email us : info@stemrx.in

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