What Is Endometrial Rejuvenation?

The endometrium is the inner lining of the uterus. Each cycle it thickens and becomes “receptive” for a short window so that an embryo can attach and grow. If the lining is too thin, scarred, inflamed or poorly supplied with blood, embryos may fail to implant even when they are of good quality.

“Endometrial rejuvenation” refers to procedures that aim to improve the condition of the lining. The most studied approach is an infusion of your own platelet-rich plasma (PRP) into the uterine cavity. PRP is a growth-factor-rich concentrate prepared from a small sample of your blood.

What it is not: endometrial rejuvenation is not a guaranteed fix for implantation failure. It cannot repair every cause, cannot make an abnormal embryo healthy, and cannot guarantee a pregnancy. Our doctors will explain this clearly before you decide.

According to the World Health Organization, about 1 in 6 adults experience infertility, and many couples need assisted reproduction to conceive.

Why Does the Uterine Lining Fail to Respond?

A thin or non-receptive endometrium is a sign, not a diagnosis. Common causes include:

• Intrauterine adhesions (Asherman syndrome) — scar tissue, often after repeated D&C, miscarriage surgery or infection.
• Chronic endometritis — low-grade uterine infection or inflammation that may have no symptoms.
• Genital tuberculosis — an important cause of damaged lining in India.
• Poor blood flow to the uterus — reduced supply of oxygen and nutrients to the lining.
• Low oestrogen or poor response to oestrogen — including in women with low ovarian reserve.
• Fibroids, polyps and adenomyosis — can distort the cavity or affect the lining.
• Previous pelvic radiation or uterine surgery.
• Long-term use of some fertility medicines — such as clomiphene, in certain women.
• Unexplained — many women have no clear cause even after evaluation.

Signs That the Lining May Be a Problem

• Thin lining on ultrasound — despite adequate oestrogen medication.
• Repeated implantation failure (RIF) — no pregnancy after several transfers of good-quality embryos.
• Very light, short or absent periods — sometimes a sign of adhesions.
• Previous D&C, uterine surgery, infection or tuberculosis.
• Recurrent early pregnancy loss.
• Pelvic pain or abnormal discharge — possible signs of infection or inflammation.

Many women have no symptoms at all, and the problem is found only when an IVF cycle does not work. That is why a careful uterine evaluation is so important.

How We Evaluate the Endometrium

Before any regenerative option, we look for causes that have a proven treatment:

Endometrial Rejuvenation Compared With Other Options

Treating the cause always comes first. Regenerative options are added only when appropriate:

What Does the Research Say?

Intrauterine PRP has more supporting research than several other regenerative procedures. A 2022 meta-analysis pooling seven randomised trials (861 women with a thin endometrium or previous implantation failure) reported higher pregnancy rates with PRP, and concluded that it may be an effective therapy. Other systematic reviews describe the earlier findings as conflicting, especially for women with thin endometrium.

The trials were small and differed in how PRP was prepared, which women were included and when it was given, so the true size of any benefit is uncertain. The authors themselves call for larger randomised studies.

In plain words: it is a reasonable option for carefully selected women once other causes have been addressed, but it is still not a guaranteed treatment, and we will not promise it as one.

How the Procedure Works at StemRx

If, after evaluation and counselling, you and your doctor decide to go ahead, the pathway is:

Step 1 — Consultation and Counselling

Your specialist reviews your IVF history, embryo quality, previous scans and uterine procedures, and explains realistic outcomes, alternatives and costs.

Step 2 — Treat the Underlying Cause

Adhesions, polyps, infection or hormonal problems are treated first, because PRP is unlikely to help if these remain.

Step 3 — Cycle Planning and Consent

The infusion is timed with your embryo transfer cycle. You receive written information and give informed consent, including that the procedure is investigational.

Step 4 — Preparation of PRP

A small sample of your own blood is drawn and spun in a centrifuge to concentrate the platelets. Because it is your own blood, the risk of allergy or rejection is very low.

Step 5 — Intrauterine Infusion

The PRP is placed into the uterine cavity through a thin, soft catheter, in a way similar to an IUI or embryo transfer. It usually takes a few minutes, needs no anaesthesia and is generally no more than mildly uncomfortable. Your protocol may involve one or two infusions.

Step 6 — Lining Check and Embryo Transfer

Your lining is re-scanned, and if it is ready, the embryo transfer goes ahead as planned. If the lining is still not suitable, your doctor may postpone the transfer, keep the embryos frozen and adjust the plan.

Possible Risks and Side Effects

• Mild cramping or spotting — common and short-lived.
• Infection — rare; prevented by sterile technique and screening.
• No benefit — some women see no improvement in lining or outcome.
• Delay or cancellation of transfer — if the lining still does not respond.
• Unknown long-term effects — long-term safety data are limited.
• Emotional strain — another attempt can bring hope and anxiety; counselling support is available.

Contact us promptly for fever, foul-smelling discharge, heavy bleeding or severe lower abdominal pain after the procedure.

Supporting Your Uterine Health

• Stay hydrated and eat a balanced diet — vegetables, fruit, whole grains, pulses and adequate protein.
• Keep active — regular gentle exercise such as walking supports circulation.
• Stop smoking and limit alcohol and caffeine — smoking is linked to poorer implantation.
• Control medical conditions — thyroid, diabetes and anaemia should be well managed.
• Avoid unnecessary D&C — repeated scraping is a common cause of adhesions.
• Report unusual symptoms early — abnormal discharge, pelvic pain or very light periods.
• Manage stress and sleep — yoga, breathing exercises or counselling during treatment.
• Be careful with supplements and home remedies — discuss anything you take with your doctor.

Why Choose StemRx for Endometrial Care?

• Cause First, Add-Ons Second — we look for adhesions, infection and hormone problems before suggesting anything experimental.
• IVF and Uterine Care Together — hysteroscopy, lining preparation, PRP and embryo transfer are coordinated by one team.
• Honest Counselling — clear explanation of what is proven, what is investigational and what to expect.
• Personalised Transfer Planning — timing based on your lining, not a template.
• Transparent Costs and Ethical Practice — clear estimates upfront, in line with applicable Indian regulations and ethical guidelines.

Patient Experiences

“[Insert genuine, consented patient testimonial about counselling and care.]” — [Name, Age]

“[Insert a second genuine, consented patient testimonial.]” — [Name, Age]

Individual results vary. Testimonials reflect personal experiences and are not a guarantee of outcome.

Frequently Asked Questions

What is considered a thin endometrium?

Many clinics use about 7 mm around the time of transfer as a lower benchmark, but there is no single cut-off. Pregnancies have occurred with thinner linings, and thickness is only one part of receptivity, along with pattern and blood flow.

Will PRP definitely thicken my lining?

No. Some women show an increase in thickness, while others do not. Your doctor will scan your lining after the infusion and adjust the plan.

Is the procedure painful?

It is similar to an IUI or embryo transfer and takes only a few minutes. Most women feel mild cramping at most, and no anaesthesia is needed.

How many sessions will I need?

It varies with your protocol. Some women have one infusion, and others have two before transfer. Your doctor will explain the plan for your cycle.

Can it help repeated IVF failure even if my lining looks normal?

Possibly in selected women, but repeated failure has many causes, including embryo chromosomes, immune and clotting factors, and uterine problems. We evaluate these before adding any procedure.

Is it the same as endometrial scratching?

No. Scratching is a minor injury to the lining, and its benefit is not consistently supported by studies. PRP is an infusion of a concentrate from your own blood.

Is it safe?

Using your own blood keeps allergy and rejection risk low, and serious complications appear to be uncommon in published studies. However, long-term safety data are limited, which is why counselling and informed consent are essential.

References

1. WHO — 1 in 6 people globally affected by infertility (2023)
2. Effects of intrauterine infusion of autologous PRP in women undergoing ART: a meta-analysis of randomized controlled trials (2022)
3. Intrauterine PRP to improve IVF outcomes in women with previous implantation failure: systematic review and meta-analysis — J Assist Reprod Genet (2023) 

Ready to Understand Why Implantation Isn’t Happening?

Speak with the StemRx fertility team for a complete uterine evaluation and an honest discussion of your options.

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